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Expression patterns of the human sarcoma-associated genes FUS and EWS and the genomic structure of FUS

Author:
  • Pierre Åman
  • Ioannis Panagopoulos
  • Carin Lassen
  • Thoas Fioretos
  • Marina Mencinger
  • Håkan Toresson
  • Mattias Höglund
  • Allan Forster
  • Terence H. Rabbitts
  • David Ron
  • Nils Mandahl
  • Felix Mitelman
Publishing year: 1996
Language: English
Pages: 1-8
Publication/Series: Genomics
Volume: 37
Issue: 1
Document type: Journal article
Publisher: Academic Press

Abstract english

FUS (TLS) was first identified as the 5'-part of a fusion gene with CHOP (GADD153, DDIT3) in myxoid liposarcomas with t(12; 16)(q13; p11). Homologies were found with the EWS oncogene, which is rearranged in Ewing sarcomas and other neoplasias. The genomic structure of FUS shows extensive similarities with that of EWS, but the exon/intron structures differ in the 5' parts, and overall FUS is smaller than EWS. Exon 3 of FUS corresponds to exons 3 and 4 in EWS. FUS exons 4-6 correspond to EWS exons 5-8. Exons 7 to 15 of FUS are very similar to those in EWS, although the EWS exons are larger than the corresponding FUS exons. FUS and EWS were expressed in all tissues investigated. The transcripts were stable within the 160-min half-life experiments. No or little variation in FUS or EWS expression was seen when resting lymphocytes were activated. These observations indicate that FUS and EWS belong to the housekeeping type of genes. This view is supported by the presence of the housekeeping gene type of promoter region in both genes.

Keywords

  • Neurology
  • Medical Genetics

Other

Published
  • ISSN: 1089-8646
Thoas Fioretos
E-mail: thoas.fioretos [at] med.lu.se

Principal investigator

Division of Clinical Genetics

+46 46 222 45 95

+46 70 334 33 67

BMC C13

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