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Effect of hypoxia on the tumor phenotype: the neuroblastoma and breast cancer models

Author:
  • Linda Holmquist Mengelbier
  • Tobias Löfstedt
  • Sven Påhlman
Publishing year: 2006
Language: English
Pages: 179-193
Publication/Series: Advances in experimental medicine and biology
Volume: 587
Document type: Conference paper
Publisher: Springer

Abstract english

The tumor oxygenation status associates with aggressive behavior. Oxygen shortage, hypoxia, is a major driving force behind tumor vascularization, and hypoxia enhances mutational rate, metastatic spread, and resistance to radiation and chemotherapy. We recently discovered that hypoxia promotes dedifferentiation of neuroblastoma and breast carcinoma cells and development of stem cell-like features. In both these tumor forms there is a correlation between low differentiation stage and poor outcome, and we conclude that the dedifferentiating effect of lowered oxygen adds to the aggressive phenotype induced by hypoxia. With neuroblastoma and breast carcinoma as human tumor model systems, we have addressed questions related to hypoxia-induced molecular mechanisms governing malignant behavior of tumor cells, with emphasis on differentiation and growth control. By global gene expression analyses we are currently screening for gene products exclusively expressed or modified in hypoxic cells with the aim to use them as targets for treatment.

Keywords

  • Cancer and Oncology
  • Animals
  • Anoxia
  • Breast Neoplasms
  • Cell Differentiation
  • Gene Expression Regulation
  • Neoplastic
  • Humans
  • Neuroblastoma
  • Phenotype

Other

Published
  • ISSN: 0065-2598
Sven Påhlman
E-mail: sven.pahlman [at] med.lu.se

Professor

Division of Translational Cancer Research

+46 46 222 64 21

MV406 312K1

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