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High levels of HIF-2alpha highlight an immature neural crest-like neuroblastoma cell cohort located in a perivascular niche.

Author:
  • Alexander Pietras
  • David Gisselsson Nord
  • Ingrid Øra
  • R Noguera
  • Siv Beckman
  • S Navarro
  • Sven Påhlman
Publishing year: 2008
Language: English
Pages: 482-488
Publication/Series: Journal of Pathology
Volume: 214
Issue: 4
Document type: Journal article
Publisher: John Wiley & Sons

Abstract english

High HIF-2alpha protein levels in the sympathetic nervous system-derived childhood tumour neuroblastoma as well as immature phenotype correlate to unfavourable outcome. Here we show that a small subset of perivascularly located, strongly HIF-2alpha-positive tumour cells (MYCN amplified) lacks expression of differentiation markers, but expresses neural crest and early sympathetic progenitor marker genes such as Notch-1, HES-1, c-Kit, dHAND, and vimentin. HIF-2alpha- and CD68-positive tumour-associated macrophages were frequently found close to the immature and HIF-2alpha-positive neuroblastoma cells and as VEGF levels are high in the perivascular niche, we hypothesize that neuroblastoma neural crest-like cells and macrophages cooperate to facilitate angiogenesis and thereby contribute to the aggressive neuroblastoma phenotype. Copyright (c) 2008 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

Keywords

  • Cancer and Oncology

Other

Published
  • CREATE Health
  • Brain Tumor Biology
  • ISSN: 0022-3417
Sven Påhlman
E-mail: sven.pahlman [at] med.lu.se

Professor

Division of Translational Cancer Research

+46 46 222 64 21

MV406 312K1

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