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A general extracorporeal immunoadsorption method to increase tumor-to-tissue ratio

Author:
  • Sven-Erik Strand
  • Kristina Norrgren
  • Michael Garkavij
  • L Lindgren
  • Rune Nilsson
  • H O Sjogren
  • Jan Tennvall
Publishing year: 1994
Language: English
Pages: 1033-1037
Publication/Series: Cancer
Volume: 73
Issue: 3 Suppl
Document type: Journal article
Publisher: John Wiley & Sons

Abstract english

The idea of applying extracorporeal immunoadsorption (ECIA) in radioimmunodiagnosis and radioimmunotherapy has been proposed previously. The authors here report on the development of new concept using a general method for ECIA based on biotinylated MoAb adsorbed on an avidin column. Athymic rats heterotransplanted with either human melanomas or human lung carcinoma were injected with iodine-125-labeled biotinylated 96.5 or L6 MoAb, respectively. At 24 or 48 hours after the injection, ECIA was performed by pumping blood through a hollow-fiber plasma filter. The separated plasma then was passed through an absorbent (avidin-agarose) column. The whole ECIA procedure lasted for 3 hours. By this ECIA method, the tumor-to-normal tissue ratios were increased in various tissues (i.e., radiosensitive and blood rich organs) by a factor of four to five.

Keywords

  • Cancer and Oncology

Other

Published
  • Medical Radiation Physics, Malmö
  • ISSN: 1097-0142
Sven-Erik Strand
E-mail: sven-erik.strand [at] med.lu.se

Project manager

Systemic Radiation Therapy Group

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Professor emeritus

Medical Radiation Physics, Lund

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