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Radio-immunotherapy dosimetry with special emphasis on SPECT quantification and extracorporeal immuno-adsorption

Author:
  • Sven-Erik Strand
  • Michael Ljungberg
  • Jan Tennvall
  • Kristina Norrgren
  • Michael Garkavij
Publishing year: 1994
Language: English
Pages: 551-561
Publication/Series: Medical & Biological Engineering & Computing
Volume: 32
Issue: 5
Document type: Journal article review
Publisher: Springer

Abstract english

Results from therapeutic trials with radiolabelled monoclonal antibodies are difficult to compare, because of lack of accurate macroscopic and microscopic dosimetry for both tumours and normal tissues. Requirements for such a dosimetry are covered in the paper. Accurate in vivo dosimetric measurement techniques for verification of calculated absorbed doses are also needed to verify treatment planning. In the review, important topics related to dosimetry in therapeutic trials in RIT are covered, such as, absorbed-dose calculations and activity-quantification techniques for planar imaging and SPECT. The latter is particularly discussed, including a summary of different correction techniques. Absorbed-dose calculations and treatment-planning techniques are also discussed. Possible ways of enhancing the therapeutic ratio are reviewed, especially the novel technique with extracorporeal immuno-adsorption. The review could form the basis of the development of future treatment-planning protocols and for dosimetry calculations in radio-immunotherapy, considering some of the most important parameters for approaching an accurate in vivo dosimetry.

Keywords

  • Other Medical Engineering
  • Absorbed dose
  • Attenuation correction
  • Extracorporeal immuno-adsorption
  • Quantification
  • Radio-immunotherapy
  • Scatter
  • SPECT

Other

Published
  • Medical Radiation Physics, Malmö
  • ISSN: 0140-0118
Sven-Erik Strand
E-mail: sven-erik.strand [at] med.lu.se

Project manager

Systemic Radiation Therapy Group

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Professor emeritus

Medical Radiation Physics, Lund

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