Optimizing retention of multimodal imaging nanostructures in sentinel lymph nodes by nanoscale size tailoring.
- Oncology and Pathology, Kamprad Lab
- Lund University Bioimaging Center
- Medical Radiation Physics, Lund
Publishing year: 2014
Publication/Series: Nanomedicine: Nanotechnology, Biology and Medicine
Document type: Journal article
This study investigates the retention of different sized ultra-small superparamagnetic iron oxide nanoparticles (USPIOs) in lymph nodes of healthy rats, after subcutaneous injection. Three distinct sizes (15, 27 and 58 nm) of USPIOs were synthesized by only varying the thickness of the polymer coating surrounding the 10 nm cores. Particles were injected on the dorsal side of the hind paw of rats and the uptake in the popliteal, inguinal and iliac lymph nodes was monitored. The data reveal that the 15 nm particle accumulates more rapidly and to a higher amount in the first lymph node than the two larger particles. A clear contrast between the first and second lymph nodes could be detected indicating that even the rather small difference in particle size (15-58 nm) tested has significant effects on the retention of USPIOs in the lymph nodes.
- Radiology, Nuclear Medicine and Medical Imaging
- ISSN: 1549-9642