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Peter James

Peter James

Professor

Peter James

Effects of insulin and the glucagon-like peptide 1 receptor agonist liraglutide on the kidney proteome in db/db mice.

Author

  • Leena Liljedahl
  • Jenny Norlin
  • James Norton McGuire
  • Peter James

Summary, in English

Diabetes mellitus (DM) is a worldwide disease that affects 9% of the adult world population and type 2 DM accounts for 90% of those. A common consequence of DM is kidney complications, which could lead to kidney failure. We studied the potential effects of treatment with insulin and the glucagon-like peptide 1 receptor (GLP-1R) agonist liraglutide on the diabetic kidney proteome through the use of the db/db mouse model system and mass spectrometry (MS). Multivariate analyses revealed distinct effects of insulin and liraglutide on the db/db kidney proteome, which was seen on the protein levels of, for example, pterin-4 α-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor-1α (PCBD1), neural precursor cell expressed developmentally down-regulated-8 (NEDD8), transcription elongation factor-B polypeptide-1 (ELOC) and hepcidin (HEPC). Furthermore, the separation of the insulin, liraglutide and vehicle db/db mouse groups in multivariate analyses was not mainly related to the albumin excretion rate (AER) or the level of glycated hemoglobin A1c (HbA1c%) in the mice. In summary, we show that insulin and liraglutide give rise to separate protein profiles in the db/db mouse kidney.

Department/s

  • Department of Immunotechnology

Publishing year

2017-03-05

Language

English

Publication/Series

Physiological Reports

Volume

5

Issue

6

Document type

Journal article

Publisher

John Wiley & Sons Inc.

Topic

  • Natural Sciences

Keywords

  • GLP‐1R agonist liraglutide
  • kidney proteome
  • OPLS‐DA
  • insulin

Status

Published

ISBN/ISSN/Other

  • ISSN: 2051-817X