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Peter James

Peter James

Professor

Peter James

The enhanced contractility of the phospholamban-deficient mouse heart persists with aging

Author

  • J. P. Slack
  • I. L. Grupp
  • R. Dash
  • D. Holder
  • A. Schmidt
  • M. J. Gerst
  • T. Tamura
  • C. Tilgmann
  • P. F. James
  • R. Johnson
  • A. M. Gerdes
  • E. G. Kranias

Summary, in English

Phospholamban ablation in the mouse is associated with significant increases in cardiac contractility. To determine whether this hyperdynamic function persists through the aging process, a longitudinal examination of age-matched phospholamban-deficient and wild-type mice was employed. Kaplan-Meier survival curves indicated no significant differences between phospholamban-deficient and wild-type mice over the first year. Examination of cardiac function revealed significant increases in the rates of contraction (+dP/dt) and relaxation (-dP/dt) in phospholamban-deficient hearts compared with their wild-type counterparts at 3, 6, 12, 18 and 24 months of age. Quantitative immunoblotting indicated that the expression levels of the sarcoplasmic reticulum Ca2+-ATPase were not altered in wild-type hearts, while they were significantly decreased at 12 months (40%) and 18 months (20%) in phospholamban-deficient hearts. These findings on the persistence of hyperdynamic cardiac function over the long terra suggest that phospholamban may constitute an important target for treatment in heart disease.

Publishing year

2001

Language

English

Pages

1031-1040

Publication/Series

Journal of Molecular and Cellular Cardiology

Volume

33

Issue

5

Document type

Journal article

Publisher

Elsevier

Keywords

  • Aging
  • Contractility
  • Myocardium
  • Phospholamban
  • Sarcoplasmic reticulum

Status

Published

ISBN/ISSN/Other

  • ISSN: 0022-2828