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Synthesis and biological evaluation of hyperforin analogues. Part I. Modification of the enolized cyclohexanedione moiety

Author:
  • L Verotta
  • G Appendino
  • E Belloro
  • F Bianchi
  • Olov Sterner
  • M Lovati
  • E Bombardelli
Publishing year: 2002
Language: English
Pages: 433-438
Publication/Series: Journal of Natural Products
Volume: 65
Issue: 4
Document type: Journal article
Publisher: The American Chemical Society

Abstract english

Modification of the St. John's wort acylphloroglucinol constituent, hyperforin (1), by acylation, alkylation, and oxidation resulted in detrimental effects on the inhibition of the synaptosomal accumulation of serotonin, showing the existence of definite structure-activity relationships in this in vitro test system and highlighting the role of the enolized cyclohexanedione moiety for activity on neurotransmitter reuptake.

Keywords

  • Organic Chemistry

Other

Published
  • ISSN: 0163-3864
Olov Sterner
E-mail: olov.sterner [at] science.lu.se

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