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Anti-trypanosomal alkaloids from Xymalos monospora

Author:
  • Dieudonne Ngarnga
  • Pierre Tane
  • Donna Rattendi
  • Cyrus Bacchi
  • Christopher C. Okunji
  • Maurice M. Iwu
  • Brian M. Schuster
  • Olov Sterner
Publishing year: 2006
Language: English
Pages: 619-622
Publication/Series: Natural Product Communications
Volume: 1
Issue: 8
Document type: Journal article
Publisher: Natural Products Inc

Abstract english

From an extract of the stem bark of Xymalos monospora, a bis-benzylisoquinoline alkaloid (1), three benzylisoquinoline alkaloids (mollinedine, 1-(p-methoxybenzyl)-6,7-methylenedioxyisoquino-line, doryafranine), and an aporphine alkaloid (N-methyllaurotetanine) were isolated. These compounds were tested for growth inhibitory activity against bloodstream forms of three strains of African trypanosomes. In vitro IC50 values starting from 1.8 mu g/mL were obtained.

Keywords

  • Organic Chemistry
  • trypanosomiasis
  • antitrypanosomal
  • alkaloids
  • Xymalos monospora
  • monimiaceae
  • sleeping sickness

Other

Published
  • ISSN: 1934-578X
Olov Sterner
E-mail: olov.sterner [at] science.lu.se

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