Menu

Javascript is not activated in your browser. This website needs javascript activated to work properly.
You are here

Cylindrocyclin A, a new cytotoxic cyclopeptide from Cylindrocarpon sp.

Author:
  • Daniela Weber
  • Gilda Erosa
  • Olov Sterner
  • Timm Anke
Publishing year: 2006
Language: English
Pages: 495-499
Publication/Series: Journal of Antibiotics
Volume: 59
Issue: 8
Document type: Journal article
Publisher: Japan Antibiotics Research Association

Abstract english

In the course of a screening of fungal extracts for new metabolites with cytotoxic activities cylindrocyclin A (1) was isolated. The producing strain was identified as Cylindrocarpon sp. by microscopy and ITS rDNA sequence analysis. 1 is a novel compound that exhibits cytotoxic acticity against six different cell lines with IC50 values ranging from 11 to 53 mu M. 1 has no antibacterial or antifungal activity. The compound is a cyclic nonapeptide comprising three alanines, five leucines and one isoleucine. Four amino acids are N-methylated. Its structure was elucidated by spectroscopic methods.

Keywords

  • Organic Chemistry
  • cylindrocarpon
  • cytotoxic
  • new metabolite
  • cyclopeptide

Other

Published
  • ISSN: 0021-8820
Olov Sterner
E-mail: olov.sterner [at] science.lu.se

Dean

Faculty of Science

+46 46 222 82 13

+46 70 530 66 49

B127

Sölvegatan 27, Lund

39

Professor

Centre for Analysis and Synthesis

+46 46 222 82 13

1