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Polyphenolic Constituents and Antioxidant Potential of Geranium stepporum Davis

Author:
  • Didem Sohretoglu
  • Mahmut Koray Sakar
  • Suna Atasayar Sabuncuoglu
  • Hilal Ozgunes
  • Olov Sterner
Publishing year: 2011
Language: English
Pages: 22-28
Publication/Series: Records of Natural Products
Volume: 5
Issue: 1
Document type: Journal article
Publisher: ACG Publications

Abstract english

The crude MeOH extract prepared from the aerial parts of G. stepporum and its EtOAc, n-BuOH, H2O subextracts were screened for their inhibitory activity on H2O2-induced lipid peroxidation in human red blood cells. The EtOAc subextract was found to be the most active one and its chemical composition was further analysed. Six polyphenolic secondary metabolites including quercetin (1), rutin (2), methyl gallate (3), pusilagin (4), 1,3,6-tri-O-galloyl-beta-glucospyranose (5) and 1,2,3,4,6-penta-O-galloyl-beta-glucopyranose (6) were isolated from the EtOAc extract by successive chromatographic methods (Sephadex CC, silica gel CC and P-TLC). The structures of the isolates were elucidated by 1D- and 2D-NMR and MS. This is the first report of occurrence of hydrolysable tannins in G. stepporum.

Keywords

  • Organic Chemistry
  • Geranium stepporum
  • Geraniaceae
  • galloylglucopyranose
  • hydrolysable
  • tannin
  • flavonoid
  • antioxidant effect

Other

Published
  • ISSN: 1307-6167
Olov Sterner
E-mail: olov.sterner [at] science.lu.se

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