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Diels-Alder adducts derived from the natural phthalide Z-ligustilide

Author:
  • Erik Lager
  • Anders Sundin
  • Ruben A. Toscano
  • Guillermo Delgado
  • Olov Sterner
Publishing year: 2007
Language: English
Pages: 4215-4218
Publication/Series: Tetrahedron Letters
Volume: 48
Issue: 24
Document type: Journal article
Publisher: Elsevier

Abstract english

Z-Ligustilide, a naturally occurring phthalide isolated from Ligusticum porteri, underwent Diels-Alder reactions with different dienophiles yielding novel tricyclic products with potentially interesting biological properties. Where selectivity was possible, the reactions performed showed regio- and stereoselectivity. The experimental results with ethyl acrylate were compared with the selectivity predicted by ab initio calculations.

Keywords

  • Organic Chemistry
  • STAT3
  • Z-ligustilide
  • galiellalactone
  • ab initio
  • Diels-Alder

Other

Published
  • ISSN: 0040-4039
Olov Sterner
E-mail: olov.sterner [at] science.lu.se

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