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Natural Pseudoguaianolides Prepared from Damsin

Author:
  • Rodrigo Villagomez
  • M. Quiroz
  • A. Tito
  • Olov Sterner
  • G. R. Almanza
Publishing year: 2015
Language: English
Pages: 675-680
Publication/Series: Chemistry of Natural Compounds
Volume: 51
Issue: 4
Document type: Journal article
Publisher: Springer

Abstract english

Damsin (1) is a pseudoguaianolide sesquiterpene possessing potent biological activities, reported as a metabolite of several medicinal plants belonging to the genus Ambrosia together with related compounds. Starting from 1, which can be isolated in good amounts from Ambrosia arborescens, the five natural pseudoguaianolides ambrosin (2), isodamsin (3), 3 alpha-hydroxydamsin (4), 3 alpha-acetoxydamsin (5), and 11 beta,13-dihydrodamsin (8) were prepared by regio- and stereo-selective synthetic modifications.

Keywords

  • Organic Chemistry
  • sesquiterpene lactones
  • pseudoguaianolides
  • semi-synthesis
  • ambrosanolides
  • derivatization
  • damsin

Other

Published
  • ISSN: 0009-3130
Olov Sterner
E-mail: olov.sterner [at] science.lu.se

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