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Synthesis of decaline analogues of isovelleral

Author:
  • Martin H Johansson
  • I Aujard
  • Daniel Röme
  • H Anke
  • Olov Sterner
Publishing year: 2005
Language: English
Pages: 984-989
Publication/Series: Zeitschrift fuer Naturforschung. Section B: A Journal of Chemical Sciences
Volume: 60
Issue: 9
Document type: Journal article
Publisher: Verlag der Zeitschrift für Naturforschung

Abstract english

Decaline analogues of the bioactive fungal sesquiterpene (+)-isovelleral (1a), retaining the bicyclo[4,1,0]hept-2-en-1,2-dicarbaldehyde system, were prepared, and their cytotoxic and antimicrobial activities were compared with those of the natural product. While the two isomers (+/-)-2 and (+/-)-3 were as active as isovelleral (1a), the isomer (+/-)-4 was approximately 10 times less potent.

Keywords

  • Organic Chemistry

Other

Published
  • ISSN: 0932-0776
Olov Sterner
E-mail: olov.sterner [at] science.lu.se

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