Menu

Javascript is not activated in your browser. This website needs javascript activated to work properly.
You are here

Benzochromenes from the roots of Bourreria pulchra

Author:
  • Gilda J. Erosa-Rejon
  • Alejandro Yam-Puc
  • Manuel J. Chan-Bacab
  • Alberto Gimenez-Turbax
  • Efrain Salamanca
  • Luis M. Pena-Rodriguez
  • Olov Sterner
Publishing year: 2010
Language: English
Pages: 9-12
Publication/Series: Phytochemistry Letters
Volume: 3
Issue: 1
Document type: Journal article
Publisher: Elsevier

Abstract english

Two new benzochromenes, (6,6-dimethyl-2-methoxy-6H-benzo[c]chromen-9-yl)methanol (1), and 2-methoxy-6,6-dimethyl-6H-benzo[c]chromen-9-carbaldehyde (2), together with several already known metabolites, were isolated from the root extract of Bourreria pulchra (Boraginaceae). The structures of 1 and 2 were established on the basis of their spectroscopic data. Both were assayed for in vitro antiprotozoan activity, and especially 1 was found to possess significant activity against Leishmania mexicana and Trypanosoma cruzi parasites (IC50 4.6 mu g/mL and 7.5 mu g/mL, respectively). (C) 2009 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.

Keywords

  • Organic Chemistry
  • Bourreria pulchra
  • Boraginaceae
  • Benzochromene
  • Antiprotozoal
  • Leishmania mexicana
  • Trypanosoma cruzi

Other

Published
  • ISSN: 1874-3900
Olov Sterner
E-mail: olov.sterner [at] science.lu.se

Dean

Faculty of Science

+46 46 222 82 13

+46 70 530 66 49

B127

Sölvegatan 27, Lund

39

Professor

Centre for Analysis and Synthesis

+46 46 222 82 13

1