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Isolation of microbial natural products.

Author:
  • Olov Sterner
Publishing year: 2012
Language: English
Pages: 393-413
Publication/Series: Methods in Molecular Biology
Volume: 864
Document type: Journal article
Publisher: Springer

Abstract english

In principle, the isolation of secondary metabolites from microbes does not differ from their isolation from other organisms. The extraction procedure may of course be quite different, especially if it is carried out in an industrial scale, but when an extract containing the metabolites of interest is at hand, it is the same palette of adsorbents and chromatographic techniques that provide the major tools for the fractionation and eventual isolation of the pure compounds. Compared to plants, in which one is sure to find secondary metabolites of certain types, e.g., flavonoids, microbes can be expected to produce virtually anything and it is important to go about the fractionation procedure with an open mind. This chapter presents an overview of preparation of extracts from microbial sources, and various methods and strategies involved in the isolation and characterization of microbial natural products.

Keywords

  • Organic Chemistry

Other

Published
  • ISSN: 1940-6029
Olov Sterner
E-mail: olov.sterner [at] science.lu.se

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