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A new P-glycoprotein inhibitor from the caper spurge (Euphorbia lathyris).

Author:
  • G Appendino
  • C Della Porta
  • G Conseil
  • Olov Sterner
  • E Mercalli
  • C Dumontet
  • A Di Pietro
Publishing year: 2003
Language: English
Pages: 140-142
Publication/Series: Journal of Natural Products
Volume: 66
Issue: 1
Document type: Journal article
Publisher: The American Chemical Society

Abstract english

The macrocyclic lathyrane polyester Euphorbia factor L10 (1a) has been obtained from the seeds of the caper spurge (E. lathyris). The interaction of L10 (1a) and its acetyl derivative (1b) with P-glycoprotein, a multidrug transporter overexpressed in cancer cells and responsible for resistance to chemotherapy, was investigated. The results established lathyrane diterpenoids as a novel chemotype for P-glycoprotein inhibitors.

Keywords

  • Organic Chemistry

Other

Published
  • ISSN: 0163-3864
Olov Sterner
E-mail: olov.sterner [at] science.lu.se

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