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Biologically active secondary metabolites from the ascomycete A111-95 - 1. Production, isolation and biological activities

Author:
  • B Kopcke
  • M Johansson
  • Olov Sterner
  • H Anke
Publishing year: 2002
Language: English
Pages: 36-40
Publication/Series: Journal of Antibiotics
Volume: 55
Issue: 1
Document type: Journal article
Publisher: Japan Antibiotics Research Association

Abstract english

Eight secondary metabolites were isolated from submerged cultures of the ascomycete A111-95 during a search for new nematicidal metabolites. (-)-Galiellalactone (7) and compound 2 are metabolites previously obtained from cultures of Galiella rufa while the compounds 1, 3, 4, 5, 6 and 8 (3 and 4 were obtained as an unseparable mixture), were isolated as natural products for the first time. Compound 2, pregaliellalactone (5) and the mixture of 3 and 4 showed nematicidal activities towards Caenorhabditis elegans and Meloidogyne incognita. All compounds showed moderate or weak cytotoxic activities.

Keywords

  • Organic Chemistry

Other

Published
  • ISSN: 0021-8820
Olov Sterner
E-mail: olov.sterner [at] science.lu.se

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