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Bioactive compounds isolated from submerged fermentations of the Chilean fungus Stereum rameale

Author:
  • Pedro Aqueveque
  • Carlos Leonardo Cespedes
  • Jose Becerra
  • Marcelo Davila
  • Olov Sterner
Publishing year: 2015
Language: English
Pages: 97-102
Publication/Series: Zeitschrift fuer Naturforschung. Section C: A Journal of Biosciences
Volume: 70
Issue: 3-4
Document type: Journal article
Publisher: Verlag der Zeitschrift für Naturforschung

Abstract english

Liquid fermentations of the fungus Stereum rameale (No 2511) yielded extracts with antibacterial -activity. The antibacterial activity reached its peak after 216 h of stirring. Bioassay-guided fractionation methods were employed for the isolation of the bioactive metabolites. Three known compounds were identified: MS-3 (1), vibralactone (2) and vibralactone B (3). The three compounds showed antibacterial activity as a function of their concentration. Minimal bactericidal concentrations (MBC) of compound 1 against Gram-positive bacteria were as follows: Bacillus cereus (50 mu g/mL), Bacillus subtilis (10 mu g/mL) and Staphylococcus aureus (100 mu g/mL). Compounds 2 and 3 were active only against Gram-negative bacteria. The MBC of compound 2 against Escherichia coli was 200 mu g/mL. Compound 3 inhibited significantly the growth of E. coli and Pseudomonas aeruginosa, with MBC values of 50 and 100 mu g/mL, respectively.

Keywords

  • Biochemistry and Molecular Biology
  • antibacterial activity
  • MIC
  • MS-3
  • Stereum rameale
  • vibralactone

Other

Published
  • ISSN: 0939-5075
Olov Sterner
E-mail: olov.sterner [at] science.lu.se

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