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Bioactive alkenylphenols from Piper obliquum.

Author:
  • Carola Valdivia
  • Nieves Marquez
  • John Eriksson
  • Antonio Vilaseca
  • Eduardo Muñoz
  • Olov Sterner
Publishing year: 2008
Language: English
Pages: 4120-4126
Publication/Series: Bioorganic & Medicinal Chemistry
Volume: 16
Issue: 7
Document type: Journal article
Publisher: Elsevier

Abstract english

Various parts of Piper obliquum Ruíz & Pavon yielded the new alkenylphenols obliquol A (1) and obliquol B (2), the new 4-chromanone 3 together with the known compounds 4 and 5. A synthesis of obliquol B (2) was developed in order to confirm its structure and to provide sufficient amounts for biological testing. Compounds 1 and 2 have antibacterial activity comparable to that of ampicillin, 2 in addition possesses potent anti-NF-kappaB activity by targeting early events in the TNFalpha-induced NF-kappaB inflammatory pathway, which may explain the effects reported for the traditional use of the plant.

Keywords

  • Organic Chemistry
  • Industrial Biotechnology

Other

Published
  • ISSN: 0968-0896
Olov Sterner
E-mail: olov.sterner [at] science.lu.se

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