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Isolation and characterization of two verrucarins from Myrothecium roridum

Author:
  • Sylvia Schoettler
  • Marcelo Bascope
  • Olov Sterner
  • Timm Anke
Publishing year: 2006
Language: English
Pages: 309-314
Publication/Series: Zeitschrift fuer Naturforschung. Section C: A Journal of Biosciences
Volume: 61
Issue: 5-6
Document type: Journal article
Publisher: Verlag der Zeitschrift für Naturforschung

Abstract english

In the course of a screening for compounds inhibiting the growth of two human breast cancer cells lines, two highly cytotoxic compounds were isolated from fermentations of Myrothecium roridum. The elucidation of their structures revealed that they are macrocyclic trichothecenes of the verrucarin type, 16-hydroxyverrucarin A (1), reported here as a natural product for the first time, and verrucarin X (2), a new compound. Both 1 and 2 exhibit moderate antifungal activity and pronounced cytotoxic activity, with IC50 values in the nanomolar (1) and micromolar (2) range. Both compounds preferentially inhibit in vivo protein biosynthesis.

Keywords

  • Organic Chemistry
  • Myrothecium roridum
  • 16-hydroxyverrucarin A
  • verrucarin X
  • protein
  • synthesis inhibitors

Other

Published
  • ISSN: 0939-5075
Olov Sterner
E-mail: olov.sterner [at] science.lu.se

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