Furanocoumarins with affinity to brain benzodiazepine receptors in vitro
- Department of Dermatology and Venereology (Lund)
- Centre for Analysis and Synthesis
Publishing year: 1997
Document type: Journal article
Eight furanocoumarins were isolated from a methanol extract of dried roots of Angelica dahurica. One of these, phellopterin, strongly (IC50 = 0.36 microM) inhibits the binding of [3H]diazepam to central nervous system benzodiazepine receptors in vitro, while the others, despite their structural similarities with phellopterin, are considerably less active.
- Dermatology and Venereal Diseases
- ISSN: 0031-9422