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Heterocycles of biological importance: Part 7. Synthesis of biologically active pyrimido[2,1-b]benzothiazoles from acetylenic acids and 2-aminobenzothiazoles

Author:
  • H Wahe
  • JT Mbafor
  • AE Nkengfack
  • ZT Fomum
  • RA Cherkasov
  • Olov Sterner
  • D Doepp
Publishing year: 2003
Language: English
Pages: 107-114
Publication/Series: Arkivoc
Volume: 2003
Issue: XV
Document type: Journal article
Publisher: Arkat USA Inc

Abstract english

Conjugate addition of the imino nitrogen of 2-aminobenzothiazoles 1 to the alkyne beta-carbon atom of acetylenic acids 2 followed by ring closure gives rise to novel 2H-pyrimido[2,1-b]-benzothiazol-2-ones in good yield.

Keywords

  • Organic Chemistry
  • fused nitrogen heterocycles
  • Michael addition
  • amidines
  • cyclocondensation

Other

Published
  • ISSN: 1551-7012
Olov Sterner
E-mail: olov.sterner [at] science.lu.se

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