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Synthesis of podoscyphic acid

Author:
  • Johan Eriksson Bajtner
  • Martin H Johansson
  • Olov Sterner
Publishing year: 2002
Language: English
Pages: 891-893
Publication/Series: Tetrahedron Letters
Volume: 43
Issue: 5
Document type: Journal article
Publisher: Elsevier

Abstract english

Podoscyphic acid 1, a fungal metabolite inhibiting RNA-directed DNA polymerises, was synthesised in four steps starting from dodecanal. The concluding ester hydrolysis of 4 was not feasible with chemical reagents, only enzymatic hydrolysis was mild enough to release the highly reactive natural product in good yields. (C) 2002 Elsevier Science Ltd. All rights reserved.

Keywords

  • Organic Chemistry
  • enzymatic hydrolysis
  • podoscyphic acid
  • synthesis lipase

Other

Published
  • ISSN: 0040-4039
Olov Sterner
E-mail: olov.sterner [at] science.lu.se

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