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Tridemethylisovelleral, a potent cytotoxic agent

Author:
  • Isabelle Aujard
  • Daniel Röme
  • Erwan Arzel
  • Martin H Johansson
  • D de Vos
  • Olov Sterner
Publishing year: 2005
Language: English
Pages: 6145-6150
Publication/Series: Bioorganic & Medicinal Chemistry
Volume: 13
Issue: 22
Document type: Journal article
Publisher: Elsevier

Abstract english

The synthesis and in vitro cytotoxicity toward various tumor cell lines of (+/-)-tridemethylisovelleral, an analogue of the bioactive fungal sesquiterpene (+)-isovelleral retaining the bicyclo[4,1,0]hept-2-en-1,2-dicarbaidehyde system but lacking the three methyl groups, is reported. The cytotoxicity of tridemethylisovelleral toward several tumor cell lines was found to be comparable with those of established antitumor drugs, and significantly higher than that of isovelleral. (c) 2005 Elsevier Ltd. All rights reserved.

Keywords

  • Organic Chemistry

Other

Published
  • ISSN: 0968-0896
Olov Sterner
E-mail: olov.sterner [at] science.lu.se

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