Tridemethylisovelleral, a potent cytotoxic agent
- Centre for Analysis and Synthesis
Publishing year: 2005
Publication/Series: Bioorganic & Medicinal Chemistry
Document type: Journal article
The synthesis and in vitro cytotoxicity toward various tumor cell lines of (+/-)-tridemethylisovelleral, an analogue of the bioactive fungal sesquiterpene (+)-isovelleral retaining the bicyclo[4,1,0]hept-2-en-1,2-dicarbaidehyde system but lacking the three methyl groups, is reported. The cytotoxicity of tridemethylisovelleral toward several tumor cell lines was found to be comparable with those of established antitumor drugs, and significantly higher than that of isovelleral. (c) 2005 Elsevier Ltd. All rights reserved.
- Organic Chemistry
- ISSN: 0968-0896