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A meroterpenoid NF-kappa B inhibitor and drimane sesquiterpenoids from asafetida

Author:
  • Giovanni Appendino
  • Lucia Maxia
  • Marcelo Bascope
  • Peter J. Houghton
  • Gonzalo Sanchez-Duffhues
  • Eduardo Munoz
  • Olov Sterner
Publishing year: 2006
Language: English
Pages: 1101-1104
Publication/Series: Journal of Natural Products
Volume: 69
Issue: 7
Document type: Journal article
Publisher: The American Chemical Society

Abstract english

Investigation of an acetone extract from asafetida afforded two drimane sesquiterpene dienones (fetidones A and B, 1a,b) and several known sesquiterpene coumarin ethers, one of which (8-acetoxy-5-hydroxyumbelliprenin, 2a) showed potent and specific NF-kappa B-inhibiting properties. This, coupled to a negligible cytotoxicity, qualifies 2a as a new anti-inflammatory chemotype, and its occurrence in asafetida might rationalize the use of this gum resin to alleviate and prevent colon inflammatory disturbances.

Keywords

  • Organic Chemistry

Other

Published
  • ISSN: 0163-3864
Olov Sterner
E-mail: olov.sterner [at] science.lu.se

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