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Synthesis of the Bioactive Benzochromenes Pulchrol and Pulchral, Metabolites of Bourreria pulchra

Author:
  • Dan Killander
  • Olov Sterner
Publishing year: 2014
Language: English
Pages: 1594-1596
Publication/Series: European Journal of Organic Chemistry
Volume: 2014
Issue: 8
Document type: Journal article
Publisher: John Wiley & Sons

Abstract english

The parasites Leshmania mexicana and Trypanosoma cruzi cause serious health problems, and few efficient treatments are available. Recently, the two benzochromenes pulchrol (1) and pulchral (2) were reported from the roots of Bourreria pulchra, and especially 1 but also 2 was found to be active towards the parasites. In this paper, we present a total synthesis of 1 and 2 to facilitate their biological evaluation. The synthesis is mild, short, and high yielding and suitable for a structure-activity relationship study.

Keywords

  • Chemical Sciences
  • Total synthesis
  • Natural products
  • Bioactive metabolites
  • Cross-coupling
  • Oxygen heterocycles

Other

Published
  • ISSN: 1434-193X
Olov Sterner
E-mail: olov.sterner [at] science.lu.se

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