Decoding breast cancer tissue-stroma interactions using species-specific sequencing.
- Division of Translational Cancer Research
Publishing year: 2015
Publication/Series: Breast Cancer Research
Document type: Journal article
Publisher: BioMed Central
Decoding transcriptional effects of experimental tissue-tissue or cell-cell interactions is important; for example, to better understand tumor-stroma interactions after transplantation of human cells into mouse (xenografting). Transcriptome analysis of intermixed human and mouse cells has, however, frequently relied on the need to separate the two cell populations prior to transcriptome analysis, which introduces confounding effects on gene expression.
- Cancer and Oncology
- ISSN: 1465-5411