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Functional homology between N-myc and c-myc in murine plasmacytomagenesis : plasmacytoma development in N-myc transgenic mice

Author:
  • Y Wang
  • H Sugiyama
  • H Axelson
  • C K Panda
  • M Babonits
  • A Ma
  • J M Steinberg
  • F W Alt
  • G Klein
  • F Wiener
Publishing year: 1992-06
Language: English
Pages: 7-1241
Publication/Series: Oncogene
Volume: 7
Issue: 6
Document type: Journal article
Publisher: Nature Publishing Group

Abstract english

Mouse plasmacytomas induced by pristane oil alone, or in combination with Abelson murine leukemia virus (A-MuLV), regularly carry one of three alternative chromosomal translocations that juxtapose c-myc to immunoglobulin heavy- or light-chain loci. E mu-c-myc transgenic mice develop translocation-free plasmacytomas after induction by pristane oil and/or A-MuLV [Sugiyama, H., Silva, S., Wang, Y., Weber, G., Babonits, M., Rosen, A., Wiener, F. & Klein, G. (1990). Int. J. Cancer, 46, 845-852]. In order to test whether another member of the myc family, N-myc, could play a similar role as c-myc, we treated E mu-N-myc transgenic mice with pristane and helper-free A-MuLV. Of 20 mice that received a single pristane injection followed by A-MuLV, 17 developed plasmacytomas with a mean latency period of 54 +/- 20 days. In a corresponding group that only received a single pristane injection, five out of six transgenic mice developed plasmacytomas with a mean latency period of 142 +/- 32 days. However, after three monthly injections of pristane, all 15 transgenic mice developed plasmacytomas with a mean latency period of 128 +/- 20 days. All plasmacytomas expressed the N-myc transgene, while none of them expressed either c-myc or endogenous N-myc. None of the tumors carried the usual plasmacytoma-associated translocations.

Keywords

  • Abelson murine leukemia virus
  • Animals
  • Carcinogens
  • DNA
  • DNA, Neoplasm
  • Enhancer Elements, Genetic
  • Genes, Immunoglobulin
  • Genes, myc
  • Immunoglobulin Heavy Chains
  • Immunoglobulin Light Chains
  • Introns
  • Mice
  • Mice, Transgenic
  • Plasmacytoma
  • RNA
  • RNA, Neoplasm
  • Terpenes
  • Translocation, Genetic

Other

Published
  • Surgery Research
  • ISSN: 0950-9232
Håkan Axelson
E-mail: hakan.axelson [at] med.lu.se

Professor

Division of Translational Cancer Research

+46 46 222 64 34

MV 404 A31A2

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