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Species diversity regarding the presence of proximal tubular progenitor cells of the kidney

Author:
  • J Hansson
  • A E Ericsson
  • Håkan Axelson
  • Martin Johansson
Publishing year: 2016
Language: English
Pages: 2567-2567
Publication/Series: European Journal of Histochemistry
Volume: 60
Issue: 1
Document type: Journal article
Publisher: SOCIETA ITALIANA DI ISTOCHIMICA

Abstract english

The cellular source for tubular regeneration following kidney injury is a matter of dispute, with reports suggesting a stem or progenitor cells as the regeneration source while linage tracing studies in mice seemingly favor the classical theory, where regeneration is performed by randomly surviving cells. We, and others have previously described a scattered cell population localized to the tubules of human kidney, which increases in number following injury. Here we have characterized the species distribution of these proximal tubular progenitor cells (PTPCs) in kidney tissue from chimpanzee, pig, rat and mouse using a set of human PTPC markers. We detected PTPCs in chimpanzee and pig kidneys, but not in mouse tissue. Also, subjecting mice to the unilateral urethral obstruction model, caused clear signs of tubular injury, but failed to induce the PTPC phenotype in renal tubules.

Keywords

  • Urology and Nephrology

Other

Published
  • Clinical pathology, Malmö
  • ISSN: 2038-8306
Håkan Axelson
E-mail: hakan.axelson [at] med.lu.se

Professor

Division of Translational Cancer Research

+46 46 222 64 34

MV 404 A31A2

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