Håkan Axelson
Research team manager
Abolished angiogenicity and tumorigenicity of Burkitt lymphoma by interleukin-10
Author
Summary, in English
Because of its immunosuppressive properties, interleukin-10 (IL-10) is thought to play an important role in a number of human disease states, including inflammation, autoimmunity, and transplant rejection. In this study, we demonstrate that introduction of human or viral IL-10 genes into Burkitt's lymphoma cells markedly reduced their ability to grow as subcutaneous (sc) tumors in SCID mice. In vivo assays for angiogenesis revealed an inhibition of the angiogenic capacity of the IL-10-transfected lines. Recombinant human IL-10 abolished and viral IL-10 reduced vascular endothelial growth factor (VEGF)-165-induced neovascularization. Furthermore, IL-10 blocked the VEGF- and fibroblast growth factor (FGF)-2-induced proliferation of microvascular endothelial cells in vitro. The current observations suggest a direct role for IL-10 in the prevention of angiogenesis in human lymphoid malignancies.
Department/s
- Division of Translational Cancer Research
Publishing year
2000-10-01
Language
English
Pages
73-2568
Publication/Series
Blood
Volume
96
Issue
7
Document type
Journal article
Publisher
American Society of Hematology
Topic
- Cancer and Oncology
Keywords
- Animals
- Burkitt Lymphoma
- Cell Division
- Cell Line
- Endothelial Growth Factors
- Endothelium, Vascular
- Fibroblast Growth Factor 2
- Gene Expression
- Interleukin-10
- Killer Cells, Natural
- Lymphokines
- Mice
- Mice, SCID
- Neoplasm Transplantation
- Neovascularization, Pathologic
- Rabbits
- Recombinant Proteins
- Transfection
- Tumor Cells, Cultured
- Vascular Endothelial Growth Factor A
- Vascular Endothelial Growth Factors
Status
Published
ISBN/ISSN/Other
- ISSN: 0006-4971