The browser you are using is not supported by this website. All versions of Internet Explorer are no longer supported, either by us or Microsoft (read more here: https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc.

Håkan Axelson

Håkan Axelson

Research team manager

Håkan Axelson

Abolished angiogenicity and tumorigenicity of Burkitt lymphoma by interleukin-10

Author

  • L Cervenak
  • L Morbidelli
  • D Donati
  • S Donnini
  • T Kambayashi
  • J L Wilson
  • H Axelson
  • E Castaños-Velez
  • H G Ljunggren
  • R D Malefyt
  • H J Granger
  • M Ziche
  • M T Bejarano

Summary, in English

Because of its immunosuppressive properties, interleukin-10 (IL-10) is thought to play an important role in a number of human disease states, including inflammation, autoimmunity, and transplant rejection. In this study, we demonstrate that introduction of human or viral IL-10 genes into Burkitt's lymphoma cells markedly reduced their ability to grow as subcutaneous (sc) tumors in SCID mice. In vivo assays for angiogenesis revealed an inhibition of the angiogenic capacity of the IL-10-transfected lines. Recombinant human IL-10 abolished and viral IL-10 reduced vascular endothelial growth factor (VEGF)-165-induced neovascularization. Furthermore, IL-10 blocked the VEGF- and fibroblast growth factor (FGF)-2-induced proliferation of microvascular endothelial cells in vitro. The current observations suggest a direct role for IL-10 in the prevention of angiogenesis in human lymphoid malignancies.

Department/s

  • Division of Translational Cancer Research

Publishing year

2000-10-01

Language

English

Pages

73-2568

Publication/Series

Blood

Volume

96

Issue

7

Document type

Journal article

Publisher

American Society of Hematology

Topic

  • Cancer and Oncology

Keywords

  • Animals
  • Burkitt Lymphoma
  • Cell Division
  • Cell Line
  • Endothelial Growth Factors
  • Endothelium, Vascular
  • Fibroblast Growth Factor 2
  • Gene Expression
  • Interleukin-10
  • Killer Cells, Natural
  • Lymphokines
  • Mice
  • Mice, SCID
  • Neoplasm Transplantation
  • Neovascularization, Pathologic
  • Rabbits
  • Recombinant Proteins
  • Transfection
  • Tumor Cells, Cultured
  • Vascular Endothelial Growth Factor A
  • Vascular Endothelial Growth Factors

Status

Published

ISBN/ISSN/Other

  • ISSN: 0006-4971