Recurring urothelial carcinomas show genomic rearrangements incompatible with a direct relationship

Summary, in English

We used the fact that patients with non-muscle invasive bladder tumors show local recurrences and multiple tumors to study re-initiation of tumor growth from the same urothelium. By extensive genomic analyses we show that tumors from the same patient are clonal. We show that gross genomic chromosomal aberrations may be detected in one tumor, only to be undetected in a recurrent tumor. By analyses of incompatible changes i.e., genomic alterations that cannot be reversed, we show that almost all tumors from a single patient may show such changes, thus the tumors cannot have originated from each other. As recurring tumors share both genomic alterations and driver gene mutations, these must have been present in the urothelium in periods with no tumor growth. We present a model that includes a growing and evolving field of urothelial cells that occasionally, and locally, produce bursts of cellular growth leading to overt tumors.

• Author: Nour Al Dain Marzouka; David Lindgren; Pontus Eriksson; Gottfrid Sjödahl; Carina Bernardo; Fredrik Liedberg; Håkan Axelson; Mattias Höglund
• Department/s: Urothelial cancer; LUCC: Lund University Cancer Centre; Urothelial Cancer Genomics; Kidney cancer research group; Division of Translational Cancer Research; Department of Laboratory Medicine
• Publishing year: 2020-12
• Language: English
• Publication/Series: Scientific Reports
• Volume: 10
• Issue: 1
• Links: http://dx.doi.org/10.1038/s41598-020-75854-4
• Document type: Journal article
• Publisher: Nature Publishing Group
• Topic: Cancer and Oncology
• Status: Published
• Research group: Urothelial Cancer Genomics; Kidney cancer research group
• ISBN/ISSN/Other: ISSN: 2045-2322