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The amino-terminal phosphorylation sites of C-MYC are frequently mutated in Burkitt's lymphoma lines but not in mouse plasmacytomas and rat immunocytomas

Author:
  • H Axelson
  • M Henriksson
  • Y Wang
  • K P Magnusson
  • G Klein
Publishing year: 1995-11
Language: English
Pages: 104-2099
Publication/Series: European Journal of Cancer
Volume: 31A
Issue: 12
Document type: Journal article
Publisher: Elsevier

Abstract english

We sequenced the region encoding the amino-terminal phosphorylation sites of C-MYC in the Ig/MYC translocation-carrying Burkitt lymphomas (BL), mouse plasmacytomas (MPC) and rat immunocytomas (RIC). Mutations affecting the Thr-58 codon or the immediate flanking region were found in seven of the 10 in vitro propagated BL lines. No mutations were found in any of the eight BL biopsies analysed. Germ-line sequences were also found in six in vivo and five in vitro passaged MPCs and in four in vivo transplanted RICs. These findings indicate that mutations in this region do not represent a general phenomena in Ig/MYC translocation-carrying tumours, but may confer growth advantage on BL cells under continuous in vitro propagation.

Keywords

  • Hematology
  • Animals
  • Base Sequence
  • Burkitt Lymphoma
  • Genes, myc
  • Humans
  • Leukemia, Lymphocytic, Chronic, B-Cell
  • Mice
  • Molecular Sequence Data
  • Phosphorylation
  • Plasmacytoma
  • Point Mutation
  • Polymerase Chain Reaction
  • Rats
  • Translocation, Genetic
  • Tumor Cells, Cultured

Other

Published
  • Surgery Research
  • ISSN: 0959-8049
Håkan Axelson
E-mail: hakan.axelson [at] med.lu.se

Professor

Division of Translational Cancer Research

+46 46 222 64 34

MV 404 A31A2

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