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Håkan Axelson

Håkan Axelson

Research team manager

Håkan Axelson

The Axl-Regulating Tumor Suppressor miR-34a Is Increased in ccRCC but Does Not Correlate with Axl mRNA or Axl Protein Levels.

Author

  • Helena Fritz
  • Anna Gustafsson
  • Börje Ljungberg
  • Yvonne Ceder
  • Håkan Axelson
  • Björn Dahlbäck

Summary, in English

High expression of the receptor tyrosine kinase Axl is associated with poor prognosis in patients with Renal Cell Carcinoma (RCC), the most common malignancy of the kidney. The miR-34a has been shown to directly regulate Axl in cancer cells. The miR-34a is a mediator of p53-dependent tumor suppression, and low expression of miR-34a has been associated with worse prognosis in several cancers. Our aim was to elucidate whether miR-34a or the other members of the miR-34 family (miR-34b/c) regulate Axl in RCC.

Department/s

  • Clinical Chemistry, Malmö
  • Division of Translational Cancer Research
  • BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation

Publishing year

2015

Language

English

Publication/Series

PLoS ONE

Volume

10

Issue

8

Document type

Journal article

Publisher

Public Library of Science (PLoS)

Topic

  • Cancer and Oncology

Status

Published

Research group

  • Clinical Chemistry, Malmö

ISBN/ISSN/Other

  • ISSN: 1932-6203