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Three exceptional IgH/myc-translocation-carrying rat immunocytomas have breakpoints 50 to 80 kb 5' of c-myc

Author:
  • H Axelson
  • C K Panda
  • G Klein
Publishing year: 1994-02-01
Language: English
Pages: 21-418
Publication/Series: International Journal of Cancer
Volume: 56
Issue: 3
Document type: Journal article
Publisher: John Wiley & Sons

Abstract english

The spontaneously arising immunocytoma of the Louvain rat (RIC) carries a consistent chromosomal translocation between chromosomes 6 and 7. This translocation juxtaposes immunoglobulin heavy chain and c-myc sequences. In an earlier study on 14 RIC tumors, we found that the translocation breakpoint is located within 1.5 kb immediately upstream of c-myc in 10 of the tumors. Here we describe 3 exceptional tumors that had no rearrangement within 20 kb 5' of c-myc. Using pulsed-field gel electrophoresis we show that the translocation breakpoints in these tumors are located 50-80 kb 5' of c-myc and that c-myc rearranges to the 3' end of the IgH cluster.

Keywords

  • Animals
  • Cell Line
  • Chromosome Mapping
  • DNA, Neoplasm
  • Genes, Immunoglobulin
  • Genes, myc
  • Immunoglobulin Heavy Chains
  • Leukemia, Lymphocytic, Chronic, B-Cell
  • Multigene Family
  • Rats
  • Rats, Inbred Strains
  • Restriction Mapping
  • Translocation, Genetic
  • Tumor Cells, Cultured

Other

Published
  • ISSN: 0020-7136
Håkan Axelson
E-mail: hakan.axelson [at] med.lu.se

Professor

Division of Translational Cancer Research

+46 46 222 64 34

MV 404 A31A2

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