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LIM-only protein Lmo2 forms a protein complex with erythroid transcription factor GATA-1

Author:
  • H Osada
  • G G Grutz
  • H Axelson
  • A Forster
  • T H Rabbitts
Publishing year: 1997-04
Language: English
Pages: 12-307
Publication/Series: Leukemia
Volume: 11
Issue: Suppl 3
Document type: Journal article
Publisher: Nature Publishing Group

Abstract english

The LIM-only protein Lmo2, originally identified as an oncogenic protein in human T cell leukemia, is essential for erythropoiesis. A possible role for Lmo2 in transcription during erythropoiesis has been investigated. Direct interaction of Lmo2 was observed in vitro and in vivo with the zinc finger transcription factor GATA-1, as well as with the basic helix-loop-helix (bHLH) transcription factor Tall. By using mammalian two-hybrid analysis, E47/Tall/Lmo2/GATA-1 protein complex could be demonstrated. Thus, a molecular link exists between three proteins crucial for erythropoiesis. This data suggest that variations in amounts of complexes involving Lmo2, Tall, and GATA-1 could be important for erythroid differentiation.

Keywords

  • Hematology
  • Adaptor Proteins, Signal Transducing
  • Animals
  • Basic Helix-Loop-Helix Transcription Factors
  • COS Cells
  • DNA-Binding Proteins
  • Erythroid-Specific DNA-Binding Factors
  • Erythropoiesis
  • GATA1 Transcription Factor
  • Helix-Loop-Helix Motifs
  • Humans
  • LIM Domain Proteins
  • Leukemia, Erythroblastic, Acute
  • Leukemia, T-Cell
  • Metalloproteins
  • Proto-Oncogene Proteins
  • Recombinant Proteins
  • Transcription Factors
  • Transcription, Genetic
  • Transfection
  • Tumor Cells, Cultured
  • Zinc Fingers

Other

Published
  • ISSN: 0887-6924
Håkan Axelson
E-mail: hakan.axelson [at] med.lu.se

Professor

Division of Translational Cancer Research

+46 46 222 64 34

MV 404 A31A2

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