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Håkan Axelson

Håkan Axelson

Research team manager

Håkan Axelson

Tracing Renal Cell Carcinomas back to the Nephron

Author

  • David Lindgren
  • Jonas Sjölund
  • Håkan Axelson

Summary, in English

Renal cell carcinomas (RCCs) are a heterogeneous group of tumors derived from the epithelial cells of the nephron. In recent years the genetic landscape of these tumors has been detailed, leading to progress in mouse modeling of the human disease. In parallel, substantial advancements have been made in describing the transcriptional programs of normal nephron cell types and how they respond to renal insults. Integrating these research fields may provide a deeper understanding of renal tumor initiation and progression, and provide leads that can be conveyed into mouse models that faithfully recapitulate the different RCC subtypes. We summarize here the genetic lesions and molecular pathways that define RCC subtypes and discuss how these relate to cell-of-origin and renal repair programs.

Department/s

  • Division of Translational Cancer Research
  • BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation

Publishing year

2018-07

Language

English

Pages

472-484

Publication/Series

Trends in Cancer

Volume

4

Issue

7

Document type

Journal article

Publisher

Cell Press

Topic

  • Cancer and Oncology

Status

Published

ISBN/ISSN/Other

  • ISSN: 2405-8033