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Perfusion assessment with bolus differentiation : a technique applicable to hyperpolarized tracers

Author:
  • Edvin Johansson
  • L E Olsson
  • S Månsson
  • J S Petersson
  • K Golman
  • F Ståhlberg
  • R Wirestam
Publishing year: 2004-11
Language: English
Pages: 51-1043
Publication/Series: Magnetic Resonance in Medicine
Volume: 52
Issue: 5
Document type: Journal article
Publisher: Wiley Online Library

Abstract english

A new technique for assessing tissue blood flow using hyperpolarized tracers, based on the fact that the magnetization of a hyperpolarized substance can be destroyed permanently, is described. Assessments of blood flow with this technique are inherently insensitive to arterial delay and dispersion, and allow for quantification of the transit time and dispersion in the arteries that supply the investigated tissue. Renal cortical blood flow was studied in six rabbits using a 13C-labeled compound (2-hydroxyethylacrylate) that was polarized by the parahydrogen-induced polarization (PHIP) technique. The renal cortical blood flow was estimated to be 5.7/5.4 +/- 1.6/1.3 ml/min per milliliter of tissue (mean +/- SD, right/left kidney), and the mean transit time and dispersion in the renal arteries were determined to be 1.47/1.42 +/- 0.07/0.07 s and 1.78/1.93 +/- 0.40/0.42 s2, respectively.

Keywords

  • Algorithms
  • Animals
  • Artifacts
  • Blood Volume
  • Carbon Isotopes
  • Image Processing, Computer-Assisted
  • Magnetic Resonance Imaging
  • Male
  • Rabbits
  • Renal Circulation
  • Statistics, Nonparametric

Other

Published
  • Medical Radiation Physics, Malmö
  • Radiology Diagnostics, Malmö
  • Hand Surgery, Malmö
  • ISSN: 0740-3194
Freddy Ståhlberg
E-mail: freddy.stahlberg [at] med.lu.se

Professor

Medical Radiation Physics, Lund

+46 46 17 31 19

+46 70 688 31 19

32

Professor

Diagnostic Radiology, (Lund)

+46 46 17 70 30

32