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Assessment of regional cerebral blood flow by dynamic susceptibility contrast MRI using different deconvolution techniques

Author:
  • Ronnie Wirestam
  • Linda Knutsson
  • Leif Ostergaard
  • Max Bolling
  • Juha-Petri Aunola
  • Arne Lindgren
  • Bo Geijer
  • Stig Holtås
  • Freddy Ståhlberg
Publishing year: 2000
Language: English
Pages: 691-700
Publication/Series: Magnetic Resonance in Medicine
Volume: 43
Issue: 5
Document type: Journal article
Publisher: Wiley Online Library

Abstract english

Regional cerebral blood flow (rCBF) was assessed using dynamic susceptibility-contrast MRI at 1.5 T. A simultaneous dual FLASH pulse sequence and Gd-DTPA-BMA (0.3 mmol/kg b.w.) were used for examination of 43 volunteers, measuring rCBF in frontal white matter (WM) and in gray matter in the thalamus (GM). Arterial input functions (AIFs) were registered 1) in the carotid artery and 2) in an artery within the GM/WM slice. The measured concentration-vs. -time curve was deconvolved with the AIF using both Fourier Transform (FT) and Singular Value Decomposition (SVD). Relative rCBF was given by the height of the deconvolved response curve. For each volunteer, eight different rCBF maps were calculated, representing different combinations of deconvolution techniques, AIFs, and filters. The average GM-WM rCBF ratios ranged from 2.0-2.2, depending on methodology. Absolute rCBF was 68 +/- 28 ml/(min 100 g) in GM and 35 +/- 13 ml/(min 100g) in WM (mean +/- SD, n = 39). GM-WM rCBF ratios obtained using SVD were 6-10% higher than corresponding ratios obtained using FT.

Keywords

  • Radiology, Nuclear Medicine and Medical Imaging
  • cerebral blood flow (CBF)
  • dynamic susceptibility-contrast magnetic resonance imaging (MRI)
  • nonparametric deconvolution
  • arterial input function

Other

Published
  • ISSN: 1522-2594
Freddy Ståhlberg
E-mail: freddy.stahlberg [at] med.lu.se

Professor

Medical Radiation Physics, Lund

+46 46 17 31 19

+46 70 688 31 19

32

Professor

Diagnostic Radiology, (Lund)

+46 46 17 70 30

32