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Dynamic susceptibility contrast MRI with a prebolus contrast agent administration design for improved absolute quantification of perfusion.

  • Linda Knutsson
  • Emelie Lind
  • André Ahlgren
  • Matthias J P van Osch
  • Karin Markenroth Bloch
  • Yulia Surova
  • Freddy Ståhlberg
  • Danielle van Westen
  • Ronnie Wirestam
Publishing year: 2014
Language: English
Pages: 996-1006
Publication/Series: Magnetic Resonance in Medicine
Volume: 72
Issue: 4
Document type: Journal article
Publisher: Wiley Online Library

Abstract english

Arterial partial-volume effects (PVEs) often hamper reproducible absolute quantification of cerebral blood flow (CBF) and cerebral blood volume (CBV) obtained by dynamic susceptibility contrast MRI (DSC-MRI). The aim of this study was to examine whether arterial PVEs in DSC-MRI data can be minimized by rescaling the arterial input function (AIF) using a sagittal-sinus venous output function obtained following a prebolus administration of a low dose of contrast agent.


  • Radiology, Nuclear Medicine and Medical Imaging


  • ISSN: 1522-2594
Freddy Ståhlberg
E-mail: freddy.stahlberg [at]


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