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Quantification of normal cerebral oxygen extraction and oxygen metabolism by phase-based MRI susceptometry: evaluation of repeatability using two different imaging protocols.

Author:
  • Robin Kämpe
  • Emelie Lind
  • Freddy Ståhlberg
  • Danielle van Westen
  • Linda Knutsson
  • Ronnie Wirestam
Publishing year: 2015-10-22
Language: English
Publication/Series: Clinical Physiology and Functional Imaging
Document type: Journal article
Publisher: Wiley Online Library

Abstract english

Global oxygen extraction fraction (OEF) and cerebral metabolic rate of oxygen (CMRO2 ) were quantified in a test-retest study. Cerebral blood flow (CBF) data, required for CMRO2 estimation, were obtained using dynamic susceptibility contrast MRI (DSC-MRI). OEF and CMRO2 were quantified using two separate data sets, that is, conventional high-resolution (HR) gradient echo (GRE) phase maps as well as echo planar imaging (EPI) phase maps taken from the baseline (precontrast) part of the DSC-MRI time series. The EPI phase data were included to elucidate whether an extra HR-GRE scan is needed to obtain information about OEF and CMRO2 , or if this information can be extracted from the DSC-MRI experiment only.

Keywords

  • Radiology, Nuclear Medicine and Medical Imaging

Other

Epub
  • ISSN: 1475-0961
Freddy Ståhlberg
E-mail: freddy.stahlberg [at] med.lu.se

Professor

Medical Radiation Physics, Lund

+46 46 17 31 19

+46 70 688 31 19

32

Professor

Diagnostic Radiology, (Lund)

+46 46 17 70 30

32