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Carl Borrebaeck

Carl Borrebaeck

Professor

Carl Borrebaeck

Design of high-density antibody microarrays for disease proteomics: Key technological issues.

Author

  • Carl Borrebaeck
  • Christer Wingren

Summary, in English

Antibody-based microarray is a novel proteomic technology setting a new standard for molecular profiling of non-fractionated complex proteomes. The first generation of antibody microarrays has already demonstrated its potential for generating detailed protein expression profiles, or protein atlases, of human body fluids in health and disease, paving the way for new discoveries within the field of disease proteomics. The process of designing highly miniaturized, high-density and high-performing antibody microarray set-ups have, however, proven to be challenging. In this mini-review we discuss key technological issues that must be addressed in a cross-disciplinary manner before true global proteome analysis can be performed using antibody microarrays.

Department/s

  • Department of Immunotechnology

Publishing year

2009

Language

English

Pages

928-935

Publication/Series

Journal of Proteomics

Volume

72

Issue

6

Document type

Journal article

Publisher

Elsevier

Topic

  • Immunology in the medical area

Status

Published

ISBN/ISSN/Other

  • ISSN: 1874-3919