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Prediction of Chemical Respiratory Sensitizers Using GARD, a Novel In Vitro Assay Based on a Genomic Biomarker Signature.

  • Andy Forreryd
  • Henrik Johansson
  • Ann-Sofie Albrekt
  • Carl Borrebaeck
  • Malin Lindstedt
Publishing year: 2015
Language: English
Publication/Series: PLoS ONE
Volume: 10
Issue: 3
Document type: Journal article
Publisher: Public Library of Science

Abstract english

Repeated exposure to certain low molecular weight (LMW) chemical compounds may result in development of allergic reactions in the skin or in the respiratory tract. In most cases, a certain LMW compound selectively sensitize the skin, giving rise to allergic contact dermatitis (ACD), or the respiratory tract, giving rise to occupational asthma (OA). To limit occurrence of allergic diseases, efforts are currently being made to develop predictive assays that accurately identify chemicals capable of inducing such reactions. However, while a few promising methods for prediction of skin sensitization have been described, to date no validated method, in vitro or in vivo, exists that is able to accurately classify chemicals as respiratory sensitizers.


  • Immunology in the medical area


  • ISSN: 1932-6203
Carl Borrebaeck
E-mail: carl.borrebaeck [at]


Department of Immunotechnology



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