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Global reprogramming of dendritic cells in response to a concerted action of inflammatory mediators

Author:
  • Malin Lindstedt
  • Bengt Johansson Lindbom
  • Carl Borrebaeck
Publishing year: 2002
Language: English
Pages: 1203-1213
Publication/Series: International Immunology
Volume: 14
Issue: 10
Document type: Journal article
Publisher: Oxford University Press

Abstract english

Maturation of dendritic cells (DC) serves a deterministic role in the link between innate and adaptive immunity, constituting a checkpoint with regard to whether responses from the lymphocyte compartment shall be raised and what class of response is needed to protect the host against invading pathogens. Since DC have not been shown to possess mechanisms such as gene recombination or somatic mutation for generating a diverse repertoire of antigen-recognition receptors, it is unlikely that these leukocytes can intrinsically respond to all conceivable molecules present in our environment. In the present study, we have therefore determined how mediators of the inflammatory response regulate global gene transcription in DC. The data represent an extensive and time-ordered reprogramming of the DC during their course of maturation, involving genes encoding proteins that regulate responses of both innate cells and lymphocytes. This transcriptional reorganization may reflect the effect of in vivo released inflammatory mediators induced by endogenous or pathogenic stimulation.

Keywords

  • Immunology in the medical area
  • inflammation
  • immunomodulator
  • cellular activation
  • dendritic cell
  • inflammatory mediator

Other

Published
  • Adaptive Immunity
  • ISSN: 1460-2377
Carl B
Carl Borrebaeck
E-mail: carl.borrebaeck [at] immun.lth.se

Professor

Department of Immunotechnology

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Director

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