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Identification of serum biomarker signatures associated with pancreatic cancer

Author:
  • Christer Wingren
  • Anna Sandström Gerdtsson
  • R. Segersvard
  • Anders Carlsson
  • Roland Andersson
  • M. Lohr
  • Carl Borrebaeck
Publishing year: 2012
Language: English
Pages: 90-2481
Publication/Series: Cancer Research
Volume: 72
Document type: Journal article
Publisher: American Association for Cancer Research Inc.

Abstract english

Pancreatic cancer is an aggressive disease with poor prognosis, due, in part, to the lack of disease-specific biomarkers that could afford early and accurate diagnosis. With a recombinant antibody microarray platform, targeting mainly immunoregulatory proteins, we screened sera from 148 patients with pancreatic cancer, chronic pancreatitis, autoimmune pancreatitis (AIP), and healthy controls (N). Serum biomarker signatures were derived from training cohorts and the predictive power was evaluated using independent test cohorts. The results identified serum portraits distinguishing pancreatic cancer from N [receiver operating characteristics area under the curve (AUC) of 0.95], chronic pancreatitis (0.86), and AIP (0.99). Importantly, a 25-serum biomarker signature discriminating pancreatic cancer from the combined group of N, chronic pancreatitis, and AIP was determined. This signature exhibited a high diagnostic potential (AUC of 0.88). In summary, we present the first prevalidated, multiplexed serum biomarker signature for diagnosis of pancreatic cancer that may improve diagnosis and prevention in premalignant diseases and in screening of high-risk individuals.

Keywords

  • Cancer and Oncology
  • Pancreatic Neoplasms/*blood
  • Middle Aged
  • Humans
  • Pancreatic Ductal/*blood
  • Carcinoma
  • Biological Markers/blood
  • 80 and over
  • Aged
  • Adolescent
  • Adult
  • Pancreatitis/diagnosis
  • Pancreatitis
  • Chronic/blood
  • Tumor Markers
  • Biological/*blood

Other

Published
  • CREATE Health
  • ISSN: 1538-7445
Carl B
Carl Borrebaeck
E-mail: carl.borrebaeck [at] immun.lth.se

Professor

Department of Immunotechnology

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Director

Create Health

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