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High-throughput proteomics using antibody microarrays

Author:
  • Christer Wingren
  • Carl Borrebaeck
Publishing year: 2004
Language: English
Pages: 355-364
Publication/Series: Espert Review of Proteomics
Volume: 1
Issue: 3
Document type: Journal article review
Publisher: Future Drugs Ltd

Abstract english

Antibody-based microarrays are a novel technology that hold great promise in proteomics. Microarrays can be printed with thousands of recombinant antibodies carrying the desired specificities, the biologic sample (e.g., an entire proteome) and any specifically bound analytes detected. The microarray patterns that are generated can then be converted into proteomic maps, or molecular fingerprints, revealing the composition of the proteome. Using this tool, global proteome analysis and protein expression profiling will thus provide new opportunities for biomarker discovery, drug target identification and disease diagnostics, as well as providing insights into disease biology. Intense work is currently underway to develop this novel technology platform into the high-throughput proteomic tool required by the research community.

Keywords

  • Immunology in the medical area

Other

Published
  • ISSN: 1744-8387
Carl B
Carl Borrebaeck
E-mail: carl.borrebaeck [at] immun.lth.se

Professor

Department of Immunotechnology

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Director

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