Menu

Javascript is not activated in your browser. This website needs javascript activated to work properly.
You are here

Expression of CD137 (4-1BB) on Human Follicular Dendritic Cells

Author:
  • Malin Lindstedt
  • Bengt Johansson Lindbom
  • Carl Borrebaeck
Publishing year: 2003
Language: English
Pages: 305-310
Publication/Series: Scandinavian Journal of Immunology
Volume: 57
Issue: 4
Document type: Journal article
Publisher: Wiley-Blackwell

Abstract english

Follicular dendritic cells (FDCs) are the antigen (Ag)-trapping accessory cells of the germinal centres (GCs), essential for the development of humoral immune responses and memory. FDCs reside in the microenvironment of secondary lymphoid tissue where Ag-activated B cells expand, and undergo isotype switching and affinity maturation prior to becoming memory B cells. In addition to delivering Ag, FDCs also provide potent nonspecific accessory signals to the B cells, which are important for the GC reaction. In this report, we show that human tonsilar FDCs express the costimulatory molecule CD137. Surface expression of CD137 on FDCs was confirmed by immunofluorescent labelling and fluorescence-activated cell sorter analysis. CD137 was also highly expressed by the human cell line HK, which displays many characteristics of in vivo FDCs. The interaction between B cells and FDCs is essential for the GC reactions, and our finding suggests that CD137 plays a role in FDC-regulated B-cell responses.

Keywords

  • Immunology in the medical area

Other

Published
  • Adaptive Immunity
  • ISSN: 1365-3083
Carl B
Carl Borrebaeck
E-mail: carl.borrebaeck [at] immun.lth.se

Professor

Department of Immunotechnology

90

Director

Create Health

+46 46 222 96 13

90