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CD4+CD57+ T cells derived from peripheral blood do not support immunoglobulin production by B cells

Author:
  • Eva Andersson
  • Mats Ohlin
  • Carl A K Borrebaeck
  • Roland Carlsson
Publishing year: 1995
Language: English
Pages: 245-253
Publication/Series: Cellular Immunology
Volume: 163
Issue: 2
Document type: Journal article
Publisher: Elsevier

Abstract english

A small subpopulation of CD4+ T cells found in peripheral blood coexpresses the CD57+ marker normally found on, e.g., NK cells. It is known that this population occurs in a higher frequency in certain diseases. The same antigen has also been shown to be expressed on CD4+ T cells derived from germinal centers. The localization of this cell population to specialized lymphoid structures suggests that it may play a role in the evolution of the antibody response following antigenic stimulation in vivo. We have examined the ability of peripheral blood helper T cells coexpressing CD57 to participate in B cell activation/differentiation and evaluated their responses to polyclonal stimulation. The CD4+CD57+ T cells do not express mRNA for a number of different cytokines or for the CD40 ligand after activation in vitro. Furthermore these cells do not induce differentiation of B cells into immunoglobulin-producing cells. Consequently, despite their CD4 phenotype and their ability to be activated, to express the IL-2 receptor, and to enter into the cell cycle, they do not act as T helper cells under conditions where CD4+/CD57- cells normally do so. The findings suggest that this peripheral blood helper T cell population is functionally different from regular CD4+ T cells. The basis for the lack of proper costimulatory signals for immunoglobulin production might be related to the low expression of CD28.

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Published
  • ISSN: 0008-8749
Carl B
Carl Borrebaeck
E-mail: carl.borrebaeck [at] immun.lth.se

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Department of Immunotechnology

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