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BRCA2 mutation in a family with hereditary prostate cancer

Author:
  • Henrik Grönberg
  • Anna-Karin Åhman
  • Monica Emanuelsson
  • Anders Bergh
  • Jan-Erik Damber
  • Åke Borg
Publishing year: 2001
Language: English
Pages: 299-301
Publication/Series: Genes, Chromosomes and Cancer
Volume: 30
Issue: 3
Document type: Journal article
Publisher: John Wiley & Sons

Abstract english

Hereditary prostate cancer is a genetically heterogeneous disease, and so far four different susceptibility loci have been identified. Reports of associated cancers are few, and it is generally considered a sire-specific disease. However, some reports have shown an elevated risk for prostate cancer among BRCA2 mutation carriers. In this report, we present a family in which the father and four of his sons were diagnosed with prostate cancer at exceptionally early ages (51, 52, 56, 58, and 63 years, respectively). In addition, three daughters were diagnosed with breast cancer between the ages of 47 and 61. In this family, a truncating mutation in exon 11, 6051delA of the BRCA2 gene, leading to an early termination of the protein (codon 1962), was identified. Although BRCA2 is probably responsible only for a very small fraction of hereditary prostate cancers, this finding supports previous reports of an increased risk of prostate cancer in BRCA2 mutation carriers.

Keywords

  • Cancer and Oncology

Other

Published
  • ISSN: 1045-2257
Åke Borg
Åke Borg
E-mail: ake.borg [at] med.lu.se

Principal investigator

Oncology and Pathology, MV

+46 46 275 25 52

MV 404 C21B2

90

Project manager

Familial Breast Cancer

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Professor

Oncology and Pathology, MV

MV 404 C21C2

90